Our services

Four connected capabilities spanning the evidence lifecycle — from the first literature search through to a defended HTA submission.

Service 01

Literature review & evidence synthesis

We turn a scattered clinical evidence base into a structured, defensible package that answers the questions HTA bodies actually ask — built to submission standard from the outset, not retrofitted afterwards.

Systematic literature review

  • Systematic reviews to submission standard
  • Targeted literature reviews
  • Rapid reviews for early decisions
  • Protocol development and PRISMA reporting

Evidence synthesis

  • Indirect treatment comparison
  • Network meta-analysis
  • Matching-adjusted indirect comparison
  • Multi-level network meta-regression

Localisation

  • Adaptation of global reports to local dossiers
  • Alignment to regional methods guidance
  • Country-specific evidence gap assessment
Researcher reviewing printed study reports in front of a bookshelf
Service 02

Health economic modelling

Economic models that translate a clinical benefit into a value argument a payer will accept — transparent in their assumptions, robust under scrutiny, and structured so a reviewer can follow every calculation.

Cost-effectiveness models

  • Early-stage and concept models
  • Global core models for local adaptation
  • Disease-agnostic model frameworks
  • Independent model QC and validation

Health economic tools

  • Budget impact models
  • Cost-consequence models
  • Cost-per-response models
  • Price–volume trade-off analysis
  • Bespoke tools built to brief

Localisation

  • Adaptation of global models to local cost bases
  • Country-specific input sourcing
  • Submission-ready model documentation
Laptop displaying a dashboard of charts and tables
Service 03

Statistical data analysis

Rigorous analysis, framed around the decision it has to support. We work from the trial data upward to produce the estimates a model needs and the evidence a regulator or payer will interrogate.

Health economics & outcomes

  • Quality of life analysis
  • Health-state utility value derivation
  • Survival analysis and extrapolation
  • Treatment switching adjustment
  • Adverse event and disutility analysis
  • Cost input derivation

Post-hoc analysis of clinical trials

  • Subgroup and sensitivity analysis
  • Re-analysis to address HTA critique
  • Analyses supporting peer-reviewed publication
  • Statistical analysis plan development
Laptop screen showing statistical analysis software
Service 04

Health technology assessment

Submission strategy and delivery across markets, from early pipeline evaluation through launch and beyond — anticipating where an assessment will be challenged, and building the evidence to meet it.

HTA & submission strategy

  • Reimbursement submission strategy
  • Predicted HTA outcome analysis
  • Risk identification and mitigation
  • Competitive benchmarking

Trial design & evidence planning

  • Development programme assessment
  • Evidence gap analysis against HTA needs
  • Endpoint and comparator selection support

Early evaluation & decision-making

  • Early pipeline asset evaluation
  • Trade-off assessment
  • Business development opportunity appraisal
Colleagues reviewing submission documents together at a table

Not sure which you need?

Most engagements draw on more than one of these. Tell us the decision you need to support and we will propose a scope.